Anti-JMJD2C Antibody (C-term)

Catalog number A04689-01

Discontinued

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About this product

Boster Bio Anti-JMJD2C Antibody (C-term) (Catalog # A04689) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number: A04689-01
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
Synonyms: Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780
Gene Name: KDM4C
UniProt: Q9H3R0
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C.
Clonality: Polyclonal
Tissue Specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs) .
Applications: WB, Flow Cytometry
Field of Research: Cancer
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Molecular Weight: 119982 Da
Shipping Conditions: Available
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment: Rabbit IgG
Subcellular Location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.

Frequently Asked Questions

What is the catalog number for Anti-JMJD2C Antibody (C-term)?

The catalog number for Anti-JMJD2C Antibody (C-term) is A04689.

Is Anti-JMJD2C Antibody (C-term) in stock?

Anti-JMJD2C Antibody (C-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-JMJD2C Antibody (C-term)?

The safety data sheet for Anti-JMJD2C Antibody (C-term) is available here: https://www.bosterbio.com/msds?sku=A04689.

What is Anti-JMJD2C Antibody (C-term) used for?

Boster Bio Anti-JMJD2C Antibody (C-term) (Catalog # A04689) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.