Anti-SOCS4 Antibody (Center)

About this product

Boster Bio Anti-SOCS4 Antibody (Center) (Catalog # A09261-1) . Tested in WB, IF, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

A09261-1-01

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Synonyms

Suppressor of cytokine signaling 4, SOCS-4, Suppressor of cytokine signaling 7, SOCS-7, SOCS4, SOCS7

Gene Name

SOCS4

UniProt

Q8WXH5

Host

Rabbit

Reactivity

Human

Immunogen

This SOCS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the Central region of human SOCS4.

Clonality

Polyclonal

Applications

WB, IF, IHC-P

Field of Research

Signal Transduction, Inflammation

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR.

Molecular Weight

50623 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

Rabbit IgG