Product details

Anti-FHIT Antibody

Catalog number M01200-1-01

Discontinued

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Size / count 80 µL

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About this product

Boster Bio Anti-FHIT Antibody (Catalog # M01200-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number: M01200-1-01
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Cleaves P (1) -P (3) -bis (5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P (1) -P (4) -bis (5'- adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P (1) -P (3) -bis (5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low- affinity Ca (2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Synonyms: Bis (5'-adenosyl) -triphosphatase, AP3A hydrolase, AP3Aase, Diadenosine 5',5'''-P1, P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein, FHIT
Gene Name: FHIT
UniProt: P49789
Host: Mouse
Reactivity: Human
Immunogen: This FHIT antibody is generated from a mouse immunized with a recombinant protein.
Clonality: Monoclonal
Clone: Clone: 1093CT23.1.2
Tissue Specificity: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung Phospho-FHIT undetected in all tested human tumor cell lines
Applications: WB, Flow Cytometry
Field of Research: Mitochondria
Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
Function: 12574506151822068794732932320795769089543008125745061518220687947329323207957690895430088794732186947471869474726181368261813681807732616407838153139151257450619622739
Molecular Weight: 16858 Da
Shipping Conditions: Available
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment: IgG1, k
Subcellular Location: Cytoplasm. Mitochondrion. Nucleus

Frequently Asked Questions

What is the catalog number for Anti-FHIT Antibody?

The catalog number for Anti-FHIT Antibody is M01200-1.

Is Anti-FHIT Antibody in stock?

Anti-FHIT Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-FHIT Antibody?

The safety data sheet for Anti-FHIT Antibody is available here: https://www.bosterbio.com/msds?sku=M01200-1.

What is Anti-FHIT Antibody used for?

Boster Bio Anti-FHIT Antibody (Catalog # M01200-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.