Anti-PDK4 Antibody

Catalog number M02132-01

Discontinued

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About this product

Boster Bio Anti-PDK4 Antibody (Catalog # M02132) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Specifications

Catalog number: M02132-01
Size / count: 80 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
Synonyms: [Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 4, mitochondrial, Pyruvate dehydrogenase kinase isoform 4, PDK4, PDHK4
Gene Name: PDK4
UniProt: Q16654
Host: Mouse
Reactivity: Human, Mouse
Immunogen: Purified His-tagged PDK4 protein (Fragment) was used to produced this monoclonal antibody.
Clonality: Monoclonal
Clone: Clone: 345CT19.6.2
Tissue Specificity: Ubiquitous; highest levels of expression in heart and skeletal muscle.
Applications: WB
Field of Research: Metabolism, Signal Transduction, Mitochondria
Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution: WB: 1:250
Function: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Molecular Weight: 46469 Da
Shipping Conditions: Available
Storage Conditions: Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment: IgG1
Subcellular Location: Mitochondrion matrix.

Frequently Asked Questions

What is the catalog number for Anti-PDK4 Antibody?

The catalog number for Anti-PDK4 Antibody is M02132.

Is Anti-PDK4 Antibody in stock?

Anti-PDK4 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-PDK4 Antibody?

The safety data sheet for Anti-PDK4 Antibody is available here: https://www.bosterbio.com/msds?sku=M02132.

What is Anti-PDK4 Antibody used for?

Boster Bio Anti-PDK4 Antibody (Catalog # M02132) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.