AF647 Anti-Mouse CD54 Antibody

About this product

This is a AF647 Anti-Mouse CD54 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

Specifications

Catalog number

RD20361F-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) . CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

Synonyms

Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1

Gene ID

15894

Swiss Prot

P13597

Reactivity

Mouse

Clonality

Monoclonal

Conjugation

AF647

Type

Flow Cytometry Antibody

Applications

FC

Assay Type

Antibody

Concentration

0.5 mg/mL

Buffer

PBS with 0.05% Proclin300, 1% BSA

Storage Conditions

Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Host or Source

Rat

Isotype

Rat IgG2b, κ