APC Anti-Mouse CD272 Antibody

About this product

This is a APC Anti-Mouse CD272 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

Specifications

Catalog number

RD20415F-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

Synonyms

B- and T-lymphocyte attenuator, Btla, B- and T-lymphocyte-associated protein, CD272, Btla

Gene ID

208154

Swiss Prot

Q7TSA3

Reactivity

Mouse

Clonality

Monoclonal

Conjugation

APC

Type

Flow Cytometry Antibody

Applications

FC

Assay Type

Antibody

Concentration

0.2 mg/mL

Buffer

PBS with 0.05% Proclin300, 1% BSA

Storage Conditions

Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Host or Source

Rat

Isotype

Rat IgG1, κ