PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63]

Catalog number HA721706

Price for HA721706

Size / count 100 µL

About this product

Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).

Specifications

Catalog number: HA721706
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CALM antibody Clathrin assembly lymphoid myeloid leukemia antibody Clathrin assembly lymphoid myeloid leukemia protein antibody CLTH antibody LAP antibody Phosphatidylinositol-binding clathrin assembly protein antibody PICAL_HUMAN antibody PICALM antibody
Abbreviation: Phosphatidylinositol-binding clathrin assembly protein Clathrin assembly lymphoid myeloid leukemia protein PICALM CALM
Swiss Prot: Q13492 Human, Q7M6Y3 Mouse, O55012 Rat
Cellular Locus: Cell membrane, Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human PICALM aa 1-450.
Isotype: IgG
Clone: PSH01-63
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P
Positive Control: HepG2 cell lysate, PC-3M cell lysate, A431 cell lysate, K-562 cell lysate, Neuro-2a cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, human breast tissue, human placenta tissue, mouse brain tissue, rat brain tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;IHC-P: 1:50
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 71 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63]?

The catalog number for PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63] is HA721706.

What sizes are available for PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63]?

PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63] is available in the following size(s): 100 µL.

Is PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63] in stock?

PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63] is currently made to order / not held in immediate stock. Contact us for lead time.

What is PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-63] used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.