DC-SIGN Recombinant Rabbit Monoclonal Antibody [JE31-24]

About this product

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens. DC-SIGN is a C-type lectin and has a high affinity for the ICAM3 molecule. It binds various microorganisms by recognizing high-mannose-containing glycoproteins on their surface, and can function as a co-receptor for several viruses such as HIV and Hepatitis C. Binding to DC-SIGN can promote HIV and Hepatitis C virus to infect target cells (T-cells and hepatocytes, respectively). Besides functioning as an adhesion molecule, recent studies have also shown that DC-SIGN can initiate innate immunity by modulating toll-like receptors, though the detailed mechanism is not yet known. DC-SIGN together with other C-type lectins is involved in recognition of tumors by dendritic cells. DC-SIGN is also a potential engineering target for dendritic cell based cancer vaccine.

Specifications

Catalog number

HA721382

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C type lectin domain family 4 member L antibody C-type lectin domain family 4 member L antibody CD 209 antibody CD209 antibody CD209 antigen antibody CD209 antigen-like protein A antibody CD209 molecule antibody CD209_HUMAN antibody Cd209a antibody CDSIGN antibody CIRE antibody CLEC4L antibody DC SIGN antibody DC SIGN1 antibody DC-SIGN antibody DC-SIGN1 antibody DCSIGN antibody Dendritic cell specific ICAM 3 grabbing nonintegrin 1 antibody Dendritic cell specific ICAM3 grabbing nonintegrin 1 antibody Dendritic cell-specific ICAM-3-grabbing non-integrin 1 antibody Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin antibody Dengue fever, protection against, included antibody Dentritic Cell Specific ICAM3 Grabbing Nonintegrin antibody HIV GP120 Binding Protein antibody MGC129965 antibody MGC130443 antibody SIGN-R1 antibody SIGNR5 antibody

Abbreviation

CD209, CLEC4L

Swiss Prot

Q9NNX6 Human

Cellular Locus

Cell membrane; Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human DC-SIGN aa 1-100 / 404.

Isotype

IgG

Clone

JE31-24

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

A549 cell lysate, human skin tissue lysate, human placenta tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 46 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes