- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
![iFluor™ 488 Conjugated SOX2 Recombinant Rabbit Monoclonal Antibody [PO00-28] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea824af/imageurl/ha720179f.webp)
Select the image to view it full size.
Product details
Catalog number HA720179F
Price for HA720179F
Size / count 100 µL
The differentiation of seminomas from non-seminomatous germ cell tumors can be challenging, especially, if small biopsy specimens, necrotic tumors and metastatic tumors with artifacts are encountered. A subset of germ cell tumors may require immunohistochemistry (IHC) for classification owing to unusual morphologic features, such as diffuse growth of clear cells, and tumors with glandular and/or microcytic patterns.1 In the mixed germ cell tumor, one component is often intermingled intimately with others such as embryonal carcinoma versus yolk sac tumor, can be overlooked. IHC will identify such an area and allow for the identification of each component of the mixed tumor more accurately and documenting them in the pathology report is recommended by WHO. Current IHC studies have shown the combination of CD30/CD117 staining plays a good role in distinguishing between embryonal carcinoma and yolk sac tumor. However, a subset of tumors may not be distinguished by this combination. Also, the characteristic membranous pattern by antibodies to CD30 and CD117 for the interpretation of the diagnosis may not be evident in limited biopsy specimens. In this respect, transcription factors, such as SOX-2, are easier to interpret due to their distinct nuclear reaction. SOX-2 has been reported as a diagnostic marker for embryonal carcinoma. SOX-2 was expressed in intratubular embryonal carcinoma, pure embryonal carcinoma and in the embryonal carcinoma component of mixed germ cell tumor in all cases. But, SOX-2 expression has not been found in seminoma, yolk sac tumor, and choriocarcinoma in almost all cases.
The catalog number for iFluor™ 488 Conjugated SOX2 Recombinant Rabbit Monoclonal Antibody [PO00-28] is HA720179F.
iFluor™ 488 Conjugated SOX2 Recombinant Rabbit Monoclonal Antibody [PO00-28] is available in the following size(s): 100 µL.
iFluor™ 488 Conjugated SOX2 Recombinant Rabbit Monoclonal Antibody [PO00-28] is currently made to order / not held in immediate stock. Contact us for lead time.
The differentiation of seminomas from non-seminomatous germ cell tumors can be challenging, especially, if small biopsy specimens, necrotic tumors and metastatic tumors with artifacts are encountered. A subset of germ cell tumors may require immunohistochemistry (IHC) for classification owing to unu
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.
Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.
Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.
