Purified Anti-Mouse CD172a Antibody[P84]

Specifications

Catalog number

E-AB-F1286A-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production.

Abbreviation

CD172a

Gene ID

19261

UniProt

P97797

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse CD172a protein

Target

Myd; SHPS; Ptpns; Bit; Myd1; Ptpns1; Shps1; Sirp; Sirpa; SIRP&beta-1-1; SIRPα SIRPβ AI835480; CD172a; P84; SHP-1; SHPS-1

Clonality

Monoclonal

Clone

P84

Conjugation

Unconjugated

Applications

FCM

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Rat IgG1, κ