Elab Fluor® 700 Anti-Mouse Foxp3 Antibody[3G3]

Specifications

Catalog number

E-AB-F1238M1-01

Size / count

50 Tests

Dry ice

No

Hazardous

No

Discontinued

No

Background

Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25) . Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence; the other (Foxp3 δ2) lacking exon 2.

Abbreviation

Foxp3

Gene ID

50943;20371;317382

UniProt

Q99JB6

Host

Mouse

Reactivity

Mouse

Target

Forkhead box protein P3; Foxp3; IPEX; JM2

Clonality

Monoclonal

Clone

3G3

Conjugation

Elab Fluor®700

Applications

FCM

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ