Purified Anti-Human CD80 Antibody[2F4]

Specifications

Catalog number

AN003450P-01

Size / count

25 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20‑100 fold higher affinity than CD28 and is involved in the down‑regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages.

Abbreviation

CD80

Gene ID

941

UniProt

P33681

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD80 protein

Target

LAB; CTLA-4 counter-receptor B; T-lymphocyte activation antigen CD; B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7; CD80; CD28LGB7-1 antigen; T-lymphocyte activation antigen CD80; Activation B7-1 antigen; CTLA-4 counter-receptor B7.1; B7-1; BB1; B lymphocyte activation antigen B7; B7-1 antigen; B7-1 antigen) ; CD28 antigen ligand 1; CD80 antigen; CD80 antigen (CD28 antigen ligand 1; CD80 molecule; Costimulatory factor CD80; costimulatory molecule variant IgV-CD80

Clonality

Monoclonal

Clone

2F4

Conjugation

Unconjugated

Applications

FCM

Field of Research

Immunology; Stem Cells

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Isotype

Mouse IgG1, κ