GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06]

Catalog number HA721884

Price for HA721884

Size / count 100 µL

About this product

G protein-coupled Receptor Kinase 6 (GRK6) is one of 7 members of the GRK serine/threonine kinase subfamily, which are known primarily for their role in desensitizing activated G protein-coupled receptors (GPCRs) . GRKs function by phosphorylating serine/threonine residues in activated GPCRs. Upon phosphorylation these residues serve as binding sites for β-arrestin proteins, inhibiting re-activation of GPCRs by blocking their re-association with G proteins . There is evidence that GRKs can also modulate selected non-GPCR signaling pathways . For example, GRK6 has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 , and the insulin-like growth factor signaling pathway. GRK6 may also play a role in immune system function. Investigators have found GRK6 expression is typically abundant in hematopoietic tumor cell lines, and a recent research study demonstrated that GRK6 suppression was selectively lethal for a number of myeloma tumor cell lines .

Specifications

Catalog number: HA721884
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FLJ32135 antibody G protein coupled receptor kinase 6 antibody G protein coupled receptor kinase GRK6 antibody G protein-coupled receptor kinase 6 antibody G protein-coupled receptor kinase GRK6 antibody Gprk6 antibody Grk6 antibody GRK6_HUMAN antibody
Abbreviation: G protein-coupled receptor kinase 6 G protein-coupled receptor kinase GRK6 GRK6 GPRK6
Swiss Prot: P43250 Human
Cellular Locus: Membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human GRK6 aa 71-120 / 576.
Isotype: IgG
Clone: JE63-06
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, FC
Positive Control: HeLa cell lysate, 293T cell lysate, Jurkat cell lysate, MCF7 cell lysate, K-562 cell lysate, A549 cell lysate, 293T.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 66 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06]?

The catalog number for GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06] is HA721884.

What sizes are available for GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06]?

GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06] is available in the following size(s): 100 µL.

Is GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06] in stock?

GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06] is currently made to order / not held in immediate stock. Contact us for lead time.

What is GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06] used for?

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.