EBP1 Recombinant Rabbit Monoclonal Antibody [JE35-48]

About this product

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation. Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. Isoform 2 interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Interacts with AKT1.

Specifications

Catalog number

HA721315

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

38kDa antibody AA672939 antibody Cell cycle protein p38 2G4 homolog antibody Cell cycle protein p38-2G4 homolog antibody ErbB-3 binding protein 1 antibody ErbB3 binding protein 1 antibody ErbB3-binding protein 1 antibody ErbB3-binding protein Ebp1 antibody hG4 1 antibody hG4-1 antibody IRES-specific cellular trans-acting factor 45 kDa antibody MGC81621 antibody MGC94070 antibody Mpp1 antibody p38 2G4 antibody Pa2g4 antibody PA2G4_HUMAN antibody Plfap antibody Proliferation associated 2G4 antibody Proliferation associated 2G4, 38-KD antibody Proliferation-associated 2G4, 38kDa antibody Proliferation-associated 2G4, a antibody Proliferation-associated protein 1 antibody Proliferation-associated protein 2G4 antibody Protein p38-2G4 antibody si:dz150i12.2 antibody wu:fb19b11 antibody wu:ft56d05 antibody zgc:86732 antibody

Abbreviation

Proliferation-associated protein 2G4 Cell cycle protein p38-2G4 homolog (hG4-1) ErbB3-binding protein 1 PA2G4 EBP1

Swiss Prot

Q9UQ80 Human, P50580 mouse, Q6AYD3

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human EBP1 aa 325-374 / 394.

Isotype

IgG

Clone

JE35-48

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

K562 cell lysate, HEK-293 cell lysate, PC-12 cell lysate, mouse cerebellum tissue, rat brain tissue, 293, NIH/3T3, PC-12.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:1,000 ;IF-Cell: 1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes