Anti-cGAS Antibody Picoband®

About this product

Boster Bio Anti-cGAS Antibody Picoband® catalog # A31676-2. Tested in WB, IHC, ICC/IF, ELISA. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

A31676-2-carrier-free

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER) . cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334) . The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.

Synonyms

M cGAS; Mb21d1; mcGAS; m-cGAS

UNSPSC

41116129

HS Code

3002.1

Gene Name

Cgas

Gene ID

214763

UniProt

Q8C6L5

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human cGAS recombinant protein (Position: A352-F504) .

Clonality

Polyclonal

Applications

WB, IHC, ICC/IF, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Storage Conditions

At -20 ̊C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20 ̊C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

58 kDa

Observed Molecular Weight

58-65 kDa

Gene Name Synonym

Cyclic GMP-AMP synthase

Protein Name

Cyclic GMP-AMP synthase

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.