Anti-Zebrafish DIO3A Antibody

About this product

Boster Bio Anti-Zebrafish DIO3A Antibody catalog # AZA0A8M1P485. Tested in IHC applications. This antibody reacts with Zebrafish.

Specifications

Catalog number

AZA0A8M1P485

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Two paralogs of this gene have been identified in zebrafish on chromosomes 17 and 20. Both encode enzymatically active proteins; however, their gene structure and tissue expression patterns are markedly different. This gene is intronless, like orthologs in all other vertebrate species studied to date, but unlike the paralog on chromosome 20, which is 2-exon. Knockdown of this gene indicates that it is essential for normal zebrafish embryonic and early larval development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

UNSPSC

41116129

HS Code

3002.1

Gene Name

DIO3A

Gene ID

100538339

UniProt

A0A8M1P485

Host

Rabbit

Reactivity

Zebrafish

Immunogen

E.coli-derived Zebrafish DIO3A recombinant protein (Position: D31-G235) .

Clonality

Polyclonal

Applications

IHC

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Gene Name Synonym

Iodothyronine deiodinase 3a

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.