ESM1 Polyclonal Antibody

Catalog number AN006090L-01

Discontinued

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Price for AN006090L-01

Size / count 25 µL

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Specifications

Catalog number: AN006090L-01
Size / count: 25 µL
Dry ice: No
Hazardous: No
Discontinued: Yes
Background: Endocan, also known as endothelial-cell specific molecule-1 (ESM-1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNF‑ alpha, IL-1 beta, or lipopolysaccharide and down-regulated by IFN‑ gamma. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen-1, LFA-1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA-1-mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
Abbreviation: Endocan/ESM-1
UniProt: Q9QYY7
Host: Rabbit
Reactivity: Human
Immunogen: Recombinant Mouse ESM1 protein expressed by Mammalian
Target: Endocan; endothelial cell specific molecule 1; endothelial cell specific molecule; Endothelial cell-specific molecule; Endocan; endothelial cell specific molecule 1; Endothelial cell-specific molecule 1; ESM-1; Esm1
Clonality: Polyclonal
Conjugation: Unconjugated
Applications: IHC
Purification: Antigen Affinity Purification
Concentration: 1 mg/mL
Dilution: IHC 1:500-1:1000
Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions: The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
Isotype: IgG

Frequently Asked Questions

What is the catalog number for ESM1 Polyclonal Antibody?

The catalog number for ESM1 Polyclonal Antibody is AN006090L.

What sizes are available for ESM1 Polyclonal Antibody?

ESM1 Polyclonal Antibody is available in the following size(s): 25 µL, 100 µL.

How many pack sizes does ESM1 Polyclonal Antibody come in?

ESM1 Polyclonal Antibody is available in 2 different pack sizes.

Is ESM1 Polyclonal Antibody in stock?

ESM1 Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ESM1 Polyclonal Antibody?

ESM1 Polyclonal Antibody is manufactured by Elabscience.

What is the estimated delivery time for ESM1 Polyclonal Antibody?

Estimated delivery time for ESM1 Polyclonal Antibody is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ESM1 Polyclonal Antibody?

The safety data sheet for ESM1 Polyclonal Antibody is available here: https://789.bio/eb/HVD8hH.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.