Recombinant Human SNCα Protein (Trx Tag)

Specifications

Catalog number

PDEH101110-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB) .

Abbreviation

SNCα

Synonyms

Fetal liver kinase; Protein-tyrosine kinase receptor flk; Vascular endothelial growth factor receptor; PD1; NACP; PARK1; PARK4; SNCA; SNC-A; aSYN; CD309; Fetal liver kinase 1; FLK1; FLK-1; KDR; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; Vascular endothelial growth factor receptor 2; VEGFR; VEGFR2; VEGFR-2; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK1; alpha (non A4 component of amyloid precursor) ; Alpha synuclein; alphaSYN; isoform NACP140; Lewy body) 4; MGC105443; MGC110988; MGC127560; MGC64356; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; Non-A4 component of amyloid; Non-A-beta component of alzheimers disease amyloid; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 4; Parkinson disease (autosomal dominant; Parkinson disease familial 1; precursor of; Snca synuclein; SYN; Synuclein; Synuclein alpha; Synuclein alpha 140; SYUA

UniProt

P37840

Accession Number

P37840

Expression System

E.coli

Tag

N-Trx

Sequence

Met1-Ala140

Field of Research

Neuroscience; Signal Transduction; Cancer

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

35.2 kDa

Observed Molecular Weight

37 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human