PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64]

Catalog number HA721707

Price for HA721707

Size / count 100 µL

About this product

Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).

Specifications

Catalog number: HA721707
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CALM antibody Clathrin assembly lymphoid myeloid leukemia antibody Clathrin assembly lymphoid myeloid leukemia protein antibody CLTH antibody LAP antibody Phosphatidylinositol-binding clathrin assembly protein antibody PICAL_HUMAN antibody PICALM antibody
Abbreviation: Phosphatidylinositol-binding clathrin assembly protein Clathrin assembly lymphoid myeloid leukemia protein PICALM CALM
Swiss Prot: Q13492 Human, Q7M6Y3 Mouse, O55012 Rat
Cellular Locus: Cell membrane, Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human PICALM aa 1-450.
Isotype: IgG
Clone: PSH01-64
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: HeLa cell lysate, HepG2 cell lysate, PC-3M cell lysate, HCT 116 cell lysate, 293T cell lysate, Neuro-2a cell lysate, PC-12 cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 71 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64]?

The catalog number for PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64] is HA721707.

What sizes are available for PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64]?

PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64] is available in the following size(s): 100 µL.

Is PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64] in stock?

PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64] is currently made to order / not held in immediate stock. Contact us for lead time.

What is PICALM Recombinant Rabbit Monoclonal Antibody [PSH01-64] used for?

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.