POMC Polyclonal Antibody

Specifications

Catalog number

AN007010L-01

Size / count

25 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Abbreviation

POMC

UniProt

P01189

Host

Rabbit

Reactivity

Mouse

Immunogen

Recombinant Human POMC protein expressed by E.coli

Target

Adrenocorticotropic hormone; Alpha melanocyte stimulating hormone; alphaMSH; Beta LPH; Beta melanocyte stimulating hormone; Corticotropin lipotropin; Corticotropin-like intermediary peptide; Gamma LPH; included; Lipotropin; Lipotropin beta; Lipotropin gamma; Melanocyte-stimulating hormone; Melanotropin; Melanotropin alpha; Melanotropin beta; Opiomelanocortin prepropeptide; Pomc1; Pomc-1; Pomc2; Pro ACTH endorphin; Pro opiomelanocortin; Proopiomelanocortin; Proopiomelanocortin preproprotein; Pro-opiomelanocortin-alpha; Tetracosactide; γ-intermedin; γ-melanocortin; γ-melanotropin; ACTH; Adrenocorticotropin; alpha-MSH; Beta-endorphin; beta-MSH; CLIP; Corticotropin; gamma-MSH; LPH; Melanotropin gamma; Met-enkephalin; MSH; NPP; POC; POMC; POMC; ACTH; CLIP; LPH; MSH; NPP; POC; Adrenocorticotropin; alpha-intermedin; alpha-melanocortin; alpha-melanotropin; b-EP; Pro-opiomelanocortin; Corticotropin-lipotropin; Gamma-MSH; Corticotropin; Alpha-MSH; Beta-LPH; Gamma-LPH; Beta-MSH; Beta-endorphin; Met-enkephalin; Melanotropin gamma; Potential peptide

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB

Purification

Antigen Affinity Purification

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000

Buffer

PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

29 kDa

Observed Molecular Weight

12 kDa

Isotype

IgG