Phospho-mTOR (S2481) Recombinant Rabbit Monoclonal Antibody [JE59-62]

About this product

The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.

Specifications

Catalog number

HA721632

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) antibody FK506 binding protein 12 rapamycin associated protein 1 antibody FK506 binding protein 12 rapamycin associated protein 2 antibody FK506 binding protein 12 rapamycin complex associated protein 1 antibody FK506-binding protein 12-rapamycin complex-associated protein 1 antibody FKBP rapamycin associated protein antibody FKBP12 rapamycin complex associated protein antibody FKBP12-rapamycin complex-associated protein 1 antibody FKBP12-rapamycin complex-associated protein antibody FLJ44809 antibody FRAP antibody FRAP1 antibody FRAP2 antibody Mammalian target of rapamycin antibody Mechanistic target of rapamycin antibody mTOR antibody MTOR_HUMAN antibody OTTHUMP00000001983 antibody RAFT1 antibody Rapamycin and FKBP12 target 1 antibody Rapamycin associated protein FRAP2 antibody Rapamycin target protein 1 antibody Rapamycin target protein antibody RAPT1 antibody Serine/threonine-protein kinase mTOR antibody

Abbreviation

MTOR

Swiss Prot

P42345 Human

Cellular Locus

Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion outer membrane, Lysosome, Cytoplasm, Nucleus, Microsome membrane, Lysosome membrane, Cytoplasmic vesicle, phagosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Ser2481 of human mTOR.

Isotype

IgG

Clone

JE59-62

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

HeLa whole cell lysate, HeLa starved overnight then treated with 200nM PMA for 4 hours whole cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:5,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 289 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes