Clusterin/Apolipoprotein J/Apo-J/CLU Monoclonal Antibody

Specifications

Catalog number

AN200024P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted protein which belongs to the clusterin family. Clusterin/Apolipoprotein J/Apo-J is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease. Its major form, a heterodimer, is secreted and present in physiological fluids, but truncated forms targeted to the nucleus have also been identified. Clusterin/Apolipoprotein J/Apo-J is a widely distributed glycoprotein with a wide range of biologic properties. A prominent and defining feature of clusterin is its marked induction in such disease states as glomerulonephritis, cystic renal disease, renal tubular injury, neurodegenerative conditions, atherosclerosis, and myocardial infarction. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.

Abbreviation

CLU

UniProt

P10909

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human Clusterin / Apolipoprotein J / Apo-J Protein

Target

KUB; AAG; Ku70-binding protein; Sulfated glycoprotein; Complement-associated protein SP; Testosterone-repressed prostate message; NA1/NA; SGP; CLU; AAG4; APO-J; APOJ; CLI; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2; TRPM2; clusterin; CLUS; Aging-associated gene 4 protein; Apolipoprotein J; Complement cytolysis inhibitor; Complement-associated protein SP-40; Ku70-binding protein 1; Sulfated glycoprotein2; Testosterone-repressed prostate message 2; Complement cytolysis inhibitor a chain; Clusterin alpha chain; Complement cytolysis inhibitor b chain; APOJ CLI; Sulfated glycoprotein 2

Clonality

Monoclonal

Clone

1F14

Conjugation

Unconjugated

Applications

WB; FCM; ICC/IF

Field of Research

Immunology; Cardiovascular; Signal Transduction; Cancer; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:1000; FCM 1:100-1:500; ICC/IF 1:100-1:500

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

52 kDa

Observed Molecular Weight

57 kDa

Isotype

IgG1