Recombinant Phospho-HER2/ErbB2 (Tyr1221, 1222) Monoclonal Antibody

Specifications

Catalog number

AN300005L-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

Abbreviation

ERBB2

UniProt

P04626

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2/ErbB2.

Target

TKR; ERBB; erb-b2 receptor tyrosine kinase; Receptor tyrosine-protein kinase erbB; Tyrosine kinase-type cell surface receptor HER; HER2/ErbB; HER; MLN; ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; erb-b2 receptor tyrosine kinase 2; HER2/ErbB2; MLN19; Metastatic lymph node gene 19 protein; p185; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; Neu; erb-B2; CD340; erb-b2 receptor tyrosine kinase 2; HER2; HER-2; HER-2/neu; MLN 19; MLN19; NGL; TKR1; C erb B2/neu protein; CD340 antigen; Cerb B2/neu protein; CerbB2; ENV; ENVW; Erb b2 receptor tyrosine kinase 2; ERVWE1; HER 2; HER 2/NEU; Herstatin; HERV7Q; HERV-7q; HERVW; HERVWENV; HERV-W-ENV; Human epidermal growth factor receptor 2; NEU proto oncogene; neuro/glioblastoma derived oncogene homolog; neuro/glioblastoma derived oncogene homolog (avian) ; Neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; Proto-oncogene c-ErbB-2; Tyrosine kinase type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) ; V erb b2 avian erythroblastic leukemia viral oncoprotein 2; V erb b2 erythroblastic leukemia viral oncogene homolog 2; Verb b2 erythroblastic leukemia viral oncogene homolog 2

Clonality

Monoclonal

Clone

1A9

Conjugation

Unconjugated

Applications

WB

Field of Research

Tags & Cell Markers; Signal Transduction; Cancer

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:10000-1:200000

Buffer

10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

138 kDa

Observed Molecular Weight

220 kDa

Isotype

IgG