Recombinant S100B Monoclonal Antibody

Specifications

Catalog number

AN300068P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell proliferation and migration and an inhibitor of apoptosis and differentiation, which might have important implications during brain, cartilage and skeletal muscle development and repair, activation of astrocytes in the course of brain damage and neurodegenerative processes, and of cardiomyocyte remodeling after infarction, as well as in melanomagenesis and gliomagenesis. As an extracellular factor, S100B engages RAGE (receptor for advanced glycation end products) in a variety of cell types with different outcomes (i.e. beneficial or detrimental, pro-proliferative or pro-differentiative) depending on the concentration attained by the protein, the cell type and the microenvironment. This calcium binding astrocyte-specific cytokine, presents a marker of astrocytic activation and reflects CNS injury. The excellent sensitivity of S100B has enabled it to confirm the existence of subtle brain injury in patients with mild head trauma, strokes, and after successful resuscitation from cardiopulmonary arrest. Recent findings provide evidence, that S100B may decrease neuronal injury and/or contribute to repair following traumatic brain injury (TBI) . Hence, S100B, far from being a negative determinant of outcome, as suggested previously in the human TBI and ischemia literature, is of potential therapeutic value that could improve outcome in patients who sustain various forms of acute brain damage.

Abbreviation

S100B

UniProt

P04271

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human S100B Protein

Target

NEF; S100; S100-B; S100beta; S100B; S100 beta; S100 calcium-binding protein B; S-100 protein beta chain; S-100 protein subunit beta; Protein S100 B; Protein S100-B; S 100 calcium binding protein beta chain; S 100 protein beta chain; S100 calcium binding protein B; S100 calcium binding protein beta (neural) ; S100 protein beta chain

Clonality

Monoclonal

Clone

10F8

Conjugation

Unconjugated

Applications

IHC-P; ICC/IF

Field of Research

Cell Biology; Epigenetics and Nuclear Signaling; Stem Cells

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:1000-1:10000; ICC/IF 1:20-1:100

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG