Recombinant Phospho-Stat6 (Tyr641) Monoclonal Antibody

Specifications

Catalog number

AN300083L-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

Abbreviation

STAT6

UniProt

P42226

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic phosphopeptide corresponding to residues around Tyr641 of the Human Stat6

Target

D12S; STAT; Signal Transducer and Activator of Transcription; D12S1644; IL-4-STAT; STAT6B; STAT6C; STAT6; IL-4 Stat; Signal Transducer and Activator of Transcription 6;12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; interleukin4 induced; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; Transcription factor IL 4 STAT

Clonality

Monoclonal

Clone

12G12

Conjugation

Unconjugated

Applications

WB

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Kits; Lysates; Other

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:2000-1:20000

Buffer

10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

94 kDa

Observed Molecular Weight

110 kDa

Isotype

IgG