Recombinant Neuropilin-1/NRP1/CD304 Monoclonal Antibody

Specifications

Catalog number

AN300099P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis.

Abbreviation

NRP1

UniProt

O14786

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human Neuropilin-1 / NRP1 / CD304 protein

Target

NPN; DKFZp686A; DKFZp781F; BDCA4; CD304; NP1; NRP; VEGF165R; Neuropilin-1; NRP1; ANG; NRP 1; NPN1; BDCA-4; DKFZp686A03134; DKFZp781F1414; Neuropilin1; CD304 antigen; neuropilin 1; Vascular endothelial cell growth factor 165 receptor; neuropilin-1; NRP1; NRPNP1

Clonality

Monoclonal

Clone

11G1

Conjugation

Unconjugated

Applications

IHC-P

Field of Research

Cardiovascular; Neuroscience; Immunology

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:50-1:200

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG