Recombinant Phospho-Stat3 (Tyr705) Monoclonal Antibody

Specifications

Catalog number

AN300142P-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Abbreviation

STAT3

UniProt

P40763

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic phosphopeptide corresponding to residues around Tyr705 of the Human Phospho-Stat3

Target

STAT; Signal Transducer and Activator of Transcription; ADMIO; ADMIO1; APRF; HIES; STAT3; Acute-Phase Response Factor; Signal Transducer and Activator of Transcription 3;1110034C02Rik; Acute Phase Response Factor; AW109958; DNA binding protein APRF; FLJ20882; MGC16063; Signal transducer and activator of transcription 3 (acute phase response factor) ; STAT 3

Clonality

Monoclonal

Clone

4B8

Conjugation

Unconjugated

Applications

WB

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Stem Cells; Cancer; Cardiovascular; Developmental Biology

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:5000

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

88 kDa

Observed Molecular Weight

90 kDa

Isotype

IgG