Recombinant MSH6/GTBP Monoclonal Antibody

Specifications

Catalog number

AN300176P-01

Size / count

20 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Abbreviation

MSH6

UniProt

P52701

Host

Rabbit

Reactivity

Human; Cynomolgus; Mouse; Rat; Ferret

Immunogen

A synthetic peptide corresponding to the center region of the Human MSH6 / GTBP

Target

MSH; mutS homolog; HNPCC; MSH6; GTBP; GTMBP; HNPCC5; HSAP; p160; mutS homolog 6; GTBP; GTMBP; HNPCC5; HSAP; mutS homolog 6; p160

Clonality

Monoclonal

Clone

8B1

Conjugation

Unconjugated

Applications

IHC-P; ICC/IF

Field of Research

Epigenetics and Nuclear Signaling

Purification

Protein A

Concentration

1 mg/mL

Dilution

IHC-P 1:100-1:500; ICC/IF 1:20-1:100

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Isotype

IgG