Recombinant SerpinA8/Angiotensinogen/AGT Monoclonal Antibody

Specifications

Catalog number

AN300213P

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10) . Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8) . Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8) . Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) . Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3 stimulates aldosterone release.Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity) . Has vasodilator and antidiuretic effects (By similarity) . Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Abbreviation

AGT

UniProt

P01019

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human SerpinA8 protein

Target

HFLT; Angiotensin 2; Angiotensin 3; AGT and SERPINA; SERPINA; Serpin A; AGT; ANHU; hFLT1; Aangiotensinogen; AGT and SERPINA8; Alpha 1 antiproteinase antitrypsin; Ang; ANGT; ANRT; AT-2; PAT; Angiotensinogen; Angiotensin-1; SERPINA8; Angiotensin-2; Angiotensin-3; Angiotensin-4; Serpin A8; Angiotensin 1-7; Angiotensin 1-10; Angiotensin I; Ang I; Angiotensin 1-8; Angiotensin II; Ang II; Angiotensin 2-8; Angiotensin III; Ang III; Angiotensin 3-8; Ang IV; Angiotensin 1-9; Angiotensin 1-5; Angiotensin 1-4; Angiotensin IV; Aangiotensinogen (serpin peptidase inhibitor clade A member 8) ; AI265500; Ang; AngII; Angiotensinogen (PAT) ; AT-II; Des-Asp[1]-angiotensin II; FLJ92595; FLJ97926; MGC105326; Pre angiotensinogen; Serine (or cysteine) proteinase inhibitor; Serpin peptidase inhibitor clade A member 8

Clonality

Monoclonal

Clone

9A4

Conjugation

Unconjugated

Applications

WB; FCM; ICC/IF; IP

Field of Research

Cardiovascular; Signal Transduction; Metabolism

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; FCM 1:25-1:100; ICC/IF 1:20-1:100; IP 4-6 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51 kDa

Observed Molecular Weight

51 kDa

Isotype

IgG