Recombinant Human CT1 Protein (Trx Tag)

Specifications

Catalog number

PDEH100518-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CTF1 is the first HOX11 protein partner identified that plays an important role in hematopoietic precursor cell immortalization. CTF1 was found to protect a gene from silencing when its DNA-binding sites were interposed between the gene and the telomeric extremity, while it did not affect a gene adjacent to the telomere. Protein fusions containing the CTF1 histone-binding domain displayed similar activities, while mutants impaired in their ability to interact with an the histone did not. Cardiotrophin-1 (CTF1) has been reported to act as a trophic factor for a few neurons, such as sensory, cholinergic, dopaminergic, motor and cortical neurons. Studies have indicated that CTF1 delays degenerative disease progression in motor neuron disease.

Abbreviation

CT1

Synonyms

Cardiophin 1; Cardiophin1; Cardiotrophin I; Cardiotrophin-1; Cardiotrophin1; CardiotrophinI; CT 1; CT-1; CT1; CTF 1; Ctf1; CTF1_HUMAN

UniProt

Q16619-1

Accession Number

Q16619-1

Expression System

E.coli

Tag

N-Trx

Sequence

Ser2-Ala201

Field of Research

Cardiovascular; Immunology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

41.8 kDa

Observed Molecular Weight

39 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human