Recombinant Human Galectin-3 Protein (His Tag)

Specifications

Catalog number

PDEH100578-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Galectin-3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3 is a beta-galactoside-binding lectin and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion, and T-cell regulation. Galectin-3 has an important role in tumor progression throμgh inhibition of apoptosis. Galectin-3 expression is associated with neoplastic transformation and with differentiation of monocytes to macrophages. Elevated expression of Galectin-3 has been demonstrated in the synovium of rheumatoid arthritis (RA) . Diseases associated with Galectin-3 include Follicular Adenoma and Papillary Carcinoma.

Abbreviation

Galectin-3

Synonyms

MAC; Galactose-specific lectin; Galactoside-Binding Soluble; Galectin; Lectin L; GAL; CBP; LGALS3; CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; Galactoside-Binding Soluble 3; Lectin; Galectin-3; Gal-3; L-31;35 kDa lectin; CBP 35; Galactose-specific lectin 3; IgE-binding protein; Laminin-binding protein; Lectin L-29; Mac-2 antigen; Carbohydrate binding protein 35; Carbohydrate-binding protein 35; galactose binding; galactoside binding soluble 3; Galactoside-binding protein; galectin 3; Galectin 3 internal gene; Galectin3; GBP; IgE binding protein; included; L 31; L 34; L-34 galactoside-binding lectin; Lectin; Galactoside-Binding Soluble 3; LEG3; MAC 2 antigen; Mac-2; Macrophage galactose-specific lectin; MGC105387; P35; soluble 3

UniProt

P17931

Accession Number

P17931

Expression System

E.coli

Tag

N-His

Sequence

2Ala-250Iie

Field of Research

Neuroscience; Cell Biology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

27.4 kDa

Observed Molecular Weight

32 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human