Recombinant Human CXCL3/CINC-2α/β Protein (Trx Tag)

Specifications

Catalog number

PDEH100600-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CXCL3/CINC-2α/β is involved in migration, invasion, proliferation and tubule formation of trophoblasts and may play a key role in the pathogenesis of preeclampsia. CXCL3/CINC-2α/β autocrine/paracrine pathways are involved in the development of prostate cancer by regulating the expression of the target genes that are related to the progression of malignancies. CXCL3/CINC-2α/β is a novel adipokine that facilitates adipogenesis in an autocrine and/or a paracrine manner throμgh induction of c/ebpb and c/ebpd. CXCL3/CINC-2α/β and its receptor CXCR2 are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis.

Abbreviation

CXCL3/CINC-2α/β

Synonyms

GRO; CXCL; SCYB; C-X-C Motif Chemokine; CINC-2b; C-X-C Motif Chemokine 3; GRO-Gamma; GRO-Gamma (1-73) ; GRO-Gamma (5-73) ; Growth-Regulated Protein Gamma; Macrophage Inflammatory Protein 2-Beta; MIP2B; MIP-2b; MIP2-Beta; CXCL3; GRO3; GROG; SCYB3

UniProt

P19876

Accession Number

P19876

Expression System

E.coli

Tag

N-Trx

Sequence

Cys35-Phe107

Field of Research

Immunology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

27.9 kDa

Observed Molecular Weight

30 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human