Recombinant Human CCL27/CTACK Protein (Sumo Tag)

Specifications

Catalog number

PDEH100602-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

CCL27/CTACK, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27/CTACK is chemotactic for skin-associated memory T lymphocytes. CCL27/CTACK may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27/CTACK plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Throμgh binding to the chemokine receptor 1 (CCR1), CCL27/CTACK mediates inflammation by promoting lymphocyte migration into the skin.

Abbreviation

CCL27/CTACK

Synonyms

CCL; SCYA; CCL27; ALP; CTACK; CTAK; ESKINE; ILC; PESKY; SCYA27; CC Chemokine ILC; C-C Motif Chemokine 27; Cutaneous T-Cell-Attracting Chemokine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; Chemokine (C-C motif) ligand 27; Cutaneous T cell attracting chemokine; IL 11 R alpha locus chemokine; member 27; Small inducible cytokine A27; small inducible cytokine subfamily A (Cys-Cys)

UniProt

Q9Y4X3

Accession Number

Q9Y4X3

Expression System

E.coli

Tag

N-Sumo

Sequence

Phe25-Gly112

Field of Research

Immunology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

22.6 kDa

Observed Molecular Weight

28 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human