Recombinant Human APOA4 Protein (Sumo Tag)

Specifications

Catalog number

PDEH100609-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD) . The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drμgs for the therapy of AD. SNP (single nucleotide polymorphisms) in APOA1and APOA4 genes influences atherogenic characteristics of LDL particles in response to diet.

Abbreviation

APOA4

Synonyms

Apolipoprotein A; APOA4; Apo AIV; APOA 4; ApoA IV; ApoAIV; ApoA-IV; Apo-AIV; Apolipoprotein A IV; Apolipoprotein A4; Apolipoprotein A-IV; MGC142154; MGC142156; APOA4; Apolipoprotein A-IV; ApoA-IV; ApoAIV; apoA4

UniProt

P06727

Accession Number

P06727

Expression System

E.coli

Tag

N-Sumo

Sequence

Ser23-Ser396

Field of Research

Signal Transduction; Cardiovascular; Cancer; Metabolism

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

54 kDa

Observed Molecular Weight

60 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human