Recombinant Human PTX3 Protein (Fc Tag)

Specifications

Catalog number

PDMH100235-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ptx3, also known as tumor necrosis factor-stimulated gene sequence-14 (TSG14), is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents. Ptx3 belongs to the family of “long pentraxins”, which have C-terminal pentraxin domains and novel amino-terminal domains. Ptx3 binds selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa and Salmonella typhimurium. It is synthesized in IgA glomerulonephritis and activates mesangial cells.

Abbreviation

PTX3

Synonyms

AI607804; Pentaxin 3; Pentaxin-related protein PTX3; Pentraxin 3 long; Pentraxin-related gene; Pentraxin-related gene rapidly induced by IL-1 beta; Pentraxin-related protein PTX3; PTX3; PTX3; TNF alpha-induced protein 5; TNFAIP5; TSG-14; TSG14; Tumor necrosis factor alpha-induced protein 5; Tumor necrosis factor-inducible gene 14 protein; Tumor necrosis factor-inducible protein TSG-14

UniProt

P26022

Accession Number

P26022

Expression System

Mammalian

Tag

C-Fc

Sequence

Glu18-Ser381

Field of Research

Cancer; Cardiovascular; Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

64.9 kDa

Observed Molecular Weight

60-80 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human