Recombinant Human PSMA Protein (Fc Tag)

Specifications

Catalog number

PDMH100295-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Glutamate carboxypeptidase 2 , also known as Glutamate carboxypeptidase II , Membrane glutamate carboxypeptidase , Prostate-specific membrane antigen , GCPII , PSMA , FOLH1 , and NAALAD1 , is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder , kidney , testis , ovary , fallopian tube , breast , adrenal gland , liver , esophagus , stomach , small intestine , colon , brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease , neural tube defects , and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.

Abbreviation

PSMA

Synonyms

GCP; GIG; Folate hydrolase; Glutamate carboxypeptidase; NAALAD; FGCP; FOLH; GCP2; GCPII; NAALAD1; NAALAdase; PSM; PSMA; mGCP; FOLH1; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Glutamate carboxypeptidase 2; NAALADase I; N-acetylated alpha-linked acidic dipeptidase 1|cell growth-inhibiting protein 27|folate hydrolase 1|folylpoly-gamma-glutamate carboxypep; GIG27; FGCP; FOLH; GCP2; GCPII; NAALAD1; NAALAdase; PSM; PSMA; mGCP; FOLH1

UniProt

Q04609

Accession Number

Q04609

Expression System

Mammalian

Tag

C-Fc

Sequence

Lys44-Ala750

Field of Research

Signal Transduction; Cancer; Metabolism

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

102.6 kDa

Observed Molecular Weight

100-110 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human