Recombinant Human ALK-1 Protein (Fc Tag)

Specifications

Catalog number

PDMH100306-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activin A receptor , type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding , a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney , spleen , heart and intestine , serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2 , also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

Abbreviation

ALK-1

Synonyms

SKR; ORW; Activin Receptor-Like Kinase; Serine/Threonine-Protein Kinase Receptor R; ACVRL; ACVRLK; ALK; ACVRL1; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I; Activin Receptor-Like Kinase 1; Serine/Threonine-Protein Kinase Receptor R3; TGF-B Superfamily Receptor Type I

UniProt

P37023

Accession Number

P37023

Expression System

Mammalian

Tag

C-Fc

Sequence

Asp22-Gln118

Field of Research

Cardiovascular; Signal Transduction; Metabolism

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

35.5 kDa

Observed Molecular Weight

50 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human