Recombinant Human CD48/SLAMF2 Protein (Fc Tag)

Specifications

Catalog number

PDMH100309-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Cluster of Differentiation 48 (CD48), also known as SLAMF2 , BCM-1 and BLAST-1 , is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion , pathogen recognition , cellular activation , and cytokine regulation , and emerges as a critical effector molecule in immune responses.

Abbreviation

CD48/SLAMF2

Synonyms

MEM; hCD; mCD; BCM; sgp; TCT; Leukocyte antigen MEM; B-lymphocyte activation marker BLAST; HM48; SLAMF; CD48; BCM1; BLAST; BLAST1; MEM-102; SLAMF2; hCD48; mCD48; BCM1 surface antigen; BLAST-1; B-lymphocyte activation marker BLAST-1; CD48 antigen; HM48-1; Leukocyte antigen MEM-102; MRC OX-45 surface antigen; sgp-60; TCT.1; BCM1; Sgp-60; SLAMF2; Antigen CD48; B cell membrane protein; B lymphocyte activation marker BLAST 1; B-cell activation marker; BCM 1 surface antigen; BLAST 1; CD 48; CD48 antigen (B cell membrane protein) ; CD48 molecule; CD48 protein; Leucocyte antigen MEM 102; MEM 102; MEM102; Signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF 2

UniProt

P09326

Accession Number

P09326

Expression System

Mammalian

Tag

C-Fc

Sequence

Gln27-Ser220

Field of Research

Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

46.2 kDa

Observed Molecular Weight

60 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human