Recombinant Human IL-23 Protein (Fc Tag)

Specifications

Catalog number

PDMH100317-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IL-23 , which is mainly secreted by antigen-presenting cells , is a member of the IL-12 family , which includes IL-12 , IL-27 , and IL-35. IL-23 is a heterodimeric cytokine , comprised of a unique p19 subunit and p4 subunit , the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1 , the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation , expansion , and survival by binding to its receptor , thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases , such as autoimmune arthritis , primary biliary cirrhosis , and inflammatory bowel disease.

Abbreviation

IL-23

Synonyms

UNQ; PRO; IL-23; IL-23A; IL23A; SGRF; UNQ2498; PRO5798

UniProt

Q9NPF7

Accession Number

Q9NPF7

Expression System

Mammalian

Tag

C-Fc

Sequence

Arg20-Pro189

Field of Research

Immunology; Microbiology; Cancer

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

43.6 kDa

Observed Molecular Weight

45 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human