Recombinant Human GITR Ligand/TNFSF18 Protein (Fc Tag)

Specifications

Catalog number

PDMH100335-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thoμght to be important for interaction between T lymphocytes and endothelial cells.

Abbreviation

GITR Ligand/TNFSF18

Synonyms

UNQ; PRO; Tnfsf; Activation-inducible TNF-related ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TNLG2A; AITRL; GITRL; TL6; TNFSF18; UNQ149; PRO175; Activation inducible TNF related ligand; AITR ligand; AITR ligand|GITR ligand|glucocorticoid-induced TNFR-related protein ligand; GITR ligand; Glucocorticoid induced TNF related ligand; Glucocorticoid induced TNFR related protein ligand; MGC138237; TNF18; Tumor necrosis factor (ligand) superfamily member 18; Tumor necrosis factor ligand 2A; Tumor necrosis factor ligand superfamily member 18

UniProt

Q9UNG2

Accession Number

Q9UNG2

Expression System

Mammalian

Tag

C-Fc

Sequence

Glu52-Ser177

Field of Research

Immunology; Tags & Cell Markers; Signal Transduction; Cancer; Cardiovascular

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.8 kDa

Observed Molecular Weight

40 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human