Recombinant Human Kallikrein 3/PSA Protein (Fc Tag)

Specifications

Catalog number

PDMH100343-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that is synthesized in the epithelial cells of the prostate gland and is present in seminal plasma. KLK3, also known as Prostate Specific antigen (PSA), kallikrein-related peptidase 3, Gamma-seminoprotein, is a secreted protein of the glandular kallikrein subfamily of serine proteases. KLK3 contains one peptidase S1 domain. KLK3 is a glycoprotein produced almost exclusively by the prostate gland. Growing evidence sμggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

Abbreviation

Kallikrein 3/PSA

Synonyms

KLK; Kallikrein; Kallikrein-Related Peptidase; KLK2A; KLK3; APS; KLK2A1; PSA; hK3; Gamma-Seminoprotein; Kallikrein-3; Kallikrein-Related Peptidase 3; P-30 Antigen; Prostate-Specific Antigen; Semenogelase; Seminin; antigen; prostate-specific; APS; Gamma seminoprotein; Gamma-seminoprotein; hK3; Kallikrein 3; Kallikrein related peptidase 3; Kallikrein-3; KLK 3; KLK2A1; Klk3; KLK3; P-30 antigen; P30 antigen; Prostate-specific antigen; Psa; Semenogelase; Seminin

UniProt

P07288

Accession Number

P07288

Expression System

Mammalian

Tag

C-Fc

Sequence

Met1-Pro261

Field of Research

Neuroscience; Tags & Cell Markers; Signal Transduction; Cancer

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

53.6 kDa

Observed Molecular Weight

60 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Human