Recombinant Mouse Fas Ligand/TNFSF6 Protein (Fc Tag)

Specifications

Catalog number

PDMM100156-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fas Ligand , also known as FASLG and CD95L , is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance , in the antigen-stimulated suicide of mature T-cells , or both.

Abbreviation

Fas Ligand/TNFSF6

Synonyms

Tnfsf; Apt1lg; IL-27p; IL-27; ALPS1B; APTL; CD178; IL; IL27-A; IL-27-A; IL-27p28; Apt1lg1; Cd95l; Fasl; gld; Tnfsf6; Faslg; Fas; CD95L; APO-1; TNFSF6; TNFRSF6; CD95L; IL-

UniProt

P41047

Accession Number

P41047

Expression System

Mammalian

Tag

C-Fc

Sequence

Pro132-Leu279

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

41.2 kDa

Observed Molecular Weight

55-60 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Mouse