Recombinant Mouse BAFF R/TNFRSF13C Protein (His Tag)

Specifications

Catalog number

PDMM100162-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Tumor necrosis factor receptor superfamily , member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen , is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor , is a trimeric cytokine receptor that binds tumor necrosis factors (TNF) . The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors , termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and , in response , they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.

Abbreviation

BAFF R/TNFRSF13C

Synonyms

Lvis;2010006P15Rik; BAFF R; BAFF-R; Bcmd1; Bcmd-1; CD268; Lvis22; Baffr; Bcmd; Br3; Tnfrsf13c; TNFRSF13c; BROMIX; CVID4; Prolixin; Tumor Necrosis Factor Receptor Superfamily Member 13C

UniProt

Q9D8D0

Accession Number

Q9D8D0

Expression System

Mammalian

Tag

C-His

Sequence

Met1-Ala71

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

7.7 kDa

Observed Molecular Weight

20 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Species

Mouse