Recombinant Human FABP3 Protein (His Tag)

Specifications

Catalog number

PDEH100670-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal-and cardiac-types. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. The FABP3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is also a candidate tumor suppressor gene for human breast cancer. FABP3 is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of onset of pain.

Abbreviation

FABP3

Synonyms

FABP11; FABP3; Fatty Acid-Binding Protein 3; Fatty Acid-Binding Protein Heart; H-FABP; Heart-Type Fatty Acid-Binding Protein; M-FABP; MDGI; MDGIMuscle Fatty Acid-Binding Protein; Mammary-Derived Growth Inhibitor; O-FABP

UniProt

P05413

Accession Number

P05413

Expression System

E.coli

Tag

N-His

Sequence

Val2-Ala133

Field of Research

Cardiovascular; metabolism; Stem cells

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

17.0 kDa

Observed Molecular Weight

15 kDa

Species

Human