Recombinant Human Pro-ADM protein (GST tag)

Specifications

Catalog number

PDEH100786-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Abbreviation

Pro-ADM

Synonyms

ADM; ADML_HUMAN; AM; Pro-adrenomedullin

UniProt

P35318

Accession Number

P35318

Expression System

E.coli

Tag

N-GST

Sequence

Arg 22-Tyr 146

Field of Research

Neuroscience

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

38.6 kDa

Observed Molecular Weight

30 kDa

Species

Human