Recombinant Human PIGR/SC protein (His tag)

Specifications

Catalog number

PDEH100808-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Polymeric immunoglobulin receptor, also known as&nbsp, PIGR, is a member of the immunoglobulin superfamily&nbsp, and a&nbsp, Fc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion of&nbsp, IgA&nbsp, and&nbsp, IgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.

Abbreviation

PIGR; SC

Synonyms

PIGR; PIgR; Poly-Ig Receptor; Polymeric Immunoglobulin Receptor

UniProt

P01833

Accession Number

P01833

Expression System

E.coli

Tag

N-His

Sequence

Lys 19-Ala 561

Field of Research

Immunology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

59.6 kDa

Observed Molecular Weight

59 kDa

Species

Human