Recombinant Human FTH protein (His tag)

Specifications

Catalog number

PDEH100828-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ferritin heavy polypeptide 1 (FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of ferritin subunit composition may affect iron absorption and release in different tissues. Deficiency of ferritin proteins may cause several neurodegenerative diseases. Almost all living organisms can produce this protein, including algae, bacteria, higher plants, and animals.

Abbreviation

FTH

Synonyms

Cell proliferation-inducing gene 15 protein; FHC; FTH; FTH1; FTHL6; Ferritin H subunit; Ferritin heavy chain; HFE5; PIG15

UniProt

P02794

Accession Number

P02794

Expression System

E.coli

Tag

N-His

Sequence

Met 1-Ser 183

Field of Research

Signal Transduction; Cardiovascular; Neuroscience; Cancer; metabolism

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

20.0 kDa

Observed Molecular Weight

28 kDa

Species

Human