Recombinant Mouse VWF protein (His tag)

Specifications

Catalog number

PDEM100259-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.

Abbreviation

VWF

Synonyms

F8VWF; VWD; VWF; Von Willebrand Factor; Vwf

UniProt

Q8CIZ8

Accession Number

Q8CIZ8

Expression System

E.coli

Tag

N-His

Sequence

Asp 1498-Val 1665

Field of Research

Cardiovascular; Cancer

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

18.4 kDa

Observed Molecular Weight

20 kDa

Species

Mouse