Recombinant Mouse CD38/ADPRC1 protein (His tag)

Specifications

Catalog number

PDEM100287-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.

Abbreviation

CD38; ADPRC1

Synonyms

ADPRC 1-rs1; ADPRC1; CD38; CD38 antigen; CD38 antigen (p45) ; CD38 molecule; Cd38; Cd38-rs1; Cyclic ADP-ribose Hydrolase; Cyclic ADP-ribose hydrolase 1; EC 3.2.2.5; I-19; NAD (+) nucleosidase; T10; cADPr hydrolase 1

UniProt

P56528

Accession Number

P56528

Expression System

E.coli

Tag

N-His

Sequence

Leu 45-Thr 304

Field of Research

Immunology; Stem Cells; Cancer; Metabolism; Microbiology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

28.5 kDa

Observed Molecular Weight

32 kDa

Species

Mouse