Recombinant Mouse IGFBP-2 / IGFBP2 protein (His tag)

Specifications

Catalog number

PDEM100304-01

Size / count

20 µg

Dry ice

No

Hazardous

No

Discontinued

No

Background

IGFBP-2, also known as IGFBP2, is a insulin-like growth factor-binding protein (IGFBP) . IGFBPs prolong the half-life of the IGFs , control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to-6) have been identified. The six IGFBPs are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates.

Abbreviation

IGFBP-2; IGFBP2

Synonyms

Igfbp2; IBP-2; IGF-binding protein 2; IGFBP-2; Insulin-like growth factor-binding protein 2; mIGFBP-2

UniProt

P47877

Accession Number

P47877

Expression System

E.coli

Tag

N-His

Sequence

Glu 35-Gln 305

Field of Research

Cancer; signal Transduction

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Calculated Molecular Weight

29.7 kDa

Observed Molecular Weight

39 kDa

Species

Mouse